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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
30.61
Human Site:
Y1145
Identified Species:
48.1
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
Y1145
P
S
G
P
D
F
N
Y
I
L
N
M
S
L
W
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
Y1153
P
S
G
P
D
F
N
Y
I
L
N
M
S
L
W
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
Y1139
P
S
G
P
D
F
N
Y
I
L
N
M
S
L
W
Dog
Lupus familis
XP_534241
2041
231068
Y1563
P
S
G
P
D
F
N
Y
I
L
N
M
S
L
W
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
Y1133
P
S
G
P
D
F
N
Y
I
L
N
M
S
L
W
Rat
Rattus norvegicus
P41516
1526
173202
W1088
D
S
D
P
V
K
A
W
K
E
A
Q
Q
K
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
Y1448
T
T
G
P
D
F
N
Y
I
L
N
M
S
L
W
Chicken
Gallus gallus
O42131
1627
183228
Y1150
T
S
G
P
D
F
N
Y
I
L
N
M
S
L
W
Frog
Xenopus laevis
NP_001082502
1579
178601
L1119
G
P
D
F
N
Y
L
L
S
M
P
L
W
Y
L
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
Y1144
F
S
G
P
N
F
N
Y
I
L
N
M
P
L
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
R1009
K
E
Y
Y
K
L
R
R
E
Y
Y
A
R
R
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
K1082
G
V
L
Q
A
Q
S
K
R
L
T
N
Q
A
R
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
G1010
L
L
R
G
E
E
E
G
L
H
K
M
F
K
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
L1035
V
K
N
M
E
I
E
L
L
K
L
E
N
K
A
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
V990
K
I
K
K
Y
N
S
V
N
E
I
L
S
E
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
100
100
100
N.A.
100
13.3
N.A.
86.6
93.3
0
80
N.A.
0
N.A.
6.6
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
93.3
93.3
26.6
86.6
N.A.
0
N.A.
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
7
0
7
0
0
0
7
7
0
7
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
14
0
47
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
7
0
0
14
7
14
0
7
14
0
7
0
7
0
% E
% Phe:
7
0
0
7
0
54
0
0
0
0
0
0
7
0
7
% F
% Gly:
14
0
54
7
0
0
0
7
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% H
% Ile:
0
7
0
0
0
7
0
0
54
0
7
0
0
0
0
% I
% Lys:
14
7
7
7
7
7
0
7
7
7
7
0
0
20
0
% K
% Leu:
7
7
7
0
0
7
7
14
14
60
7
14
0
54
14
% L
% Met:
0
0
0
7
0
0
0
0
0
7
0
60
0
0
0
% M
% Asn:
0
0
7
0
14
7
54
0
7
0
54
7
7
0
0
% N
% Pro:
34
7
0
60
0
0
0
0
0
0
7
0
7
0
0
% P
% Gln:
0
0
0
7
0
7
0
0
0
0
0
7
14
0
0
% Q
% Arg:
0
0
7
0
0
0
7
7
7
0
0
0
7
7
14
% R
% Ser:
0
54
0
0
0
0
14
0
7
0
0
0
54
0
0
% S
% Thr:
14
7
0
0
0
0
0
0
0
0
7
0
0
0
0
% T
% Val:
7
7
0
0
7
0
0
7
0
0
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
7
0
0
0
0
7
0
54
% W
% Tyr:
0
0
7
7
7
7
0
54
0
7
7
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _